Tunisia's moderate Islamists win landmark vote

Tunisian leader and founder of the moderate islamist party Ennahda, Rached Ghannouchi, center right, chairs an executive board at the party's headquarters in Tunis, Thursday, Oct. 27, 2011. Authorities say the latest results from Tunisia's landmark elections indicate the moderate Islamist party is holding onto its lead, taking at least 44 percent of seats counted so far for an assembly tasked with writing a new constitution. (AP Photo/Benjamin Girette)

Tunisian leader and founder of the moderate islamist party Ennahda, Rached Ghannouchi, center right, chairs an executive board at the party's headquarters in Tunis, Thursday, Oct. 27, 2011. Authorities say the latest results from Tunisia's landmark elections indicate the moderate Islamist party is holding onto its lead, taking at least 44 percent of seats counted so far for an assembly tasked with writing a new constitution. (AP Photo/Benjamin Girette)

Tunisian leader and founder of the moderate islamist party Ennahda, Rached Ghannouchi, chairs an executive board at the party's headquarters in Tunis, Thursday, Oct. 27, 2011. Authorities say the latest results from Tunisia's landmark elections indicate the moderate Islamist party is holding onto its lead, taking at least 44 percent of seats counted so far for an assembly tasked with writing a new constitution. (AP Photo/Benjamin Girette)

Tunisian leader and founder of the moderate islamist party Ennahda, Rached Ghannouchi, chairs an executive board at the party's headquarters in Tunis, Thursday, Oct. 27, 2011. Authorities say the latest results from Tunisia's landmark elections indicate the moderate Islamist party is holding onto its lead, taking at least 44 percent of seats counted so far for an assembly tasked with writing a new constitution. (AP Photo/Benjamin Girette)

The Tunisian leader of the moderate Islamist party, Ennahda or Renaissance, Rachid Ghannouchi, is pictured as he gets into an elevator at his party's headquarters in Tunis, Thursday, Oct. 27, 2011, Authorities say the latest results from Tunisia's landmark elections indicate the moderate Islamist party is holding onto its lead, taking at least 44 percent of seats counted so far for an assembly tasked with writing a new constitution. (AP Photo/Amine Landoulsi)

The Tunisian leader of the moderate Islamist party, Ennahda or Renaissance, Rachid Ghannouchi, arrives at his party's headquarters in Tunis, Thursday, Oct. 27, 2011. Authorities say the latest results from Tunisia's landmark elections indicate the moderate Islamist party is holding onto its lead, taking at least 44 percent of seats counted so far for an assembly tasked with writing a new constitution. (AP Photo/Amine Landoulsi)

(AP) ? Tunisia's moderate Islamist party Ennahda, banned for decades, emerged the official victor in the nation's first free elections, taking 41.47 percent of the vote and 90 of 217 seats in an assembly that will write a new constitution, the electoral commission announced Thursday.

The announcement of final results in Sunday's landmark voting capped an ebullient period for this small North African country, which inspired the Arab Spring as it moves toward democracy after more than a half-century under one-party systems.

However, protests linked to the party placing fourth in Sunday's voting erupted in and around Sidi Bouzid, the town where the uprising that drove this North African nation's strongman from power.

The leader of Areedha Chaabiya, or Popular Petition party, Hachemi Hamdi, announced on national television that he was withdrawing the 19 seats his party won after the electoral commission invalidated six of its lists.

The results carried other surprises, like the second place, and 30 seats, won by the Congress for the Republic party, founded in 2001 by noted human rights activist Moncef Marzouki, a doctor who had lived in exile in Paris.

The third-placed party was the center-left Ettakatol, or the Democratic Forum for Labor and Freedoms, led by Mustapha Ben Jaafar, also a doctor. It won 21 seats in the constituent assembly.

The final results remain provisional until after any appeals are studied, a process that could take up to two weeks, according to Ridha Torkhani, a member of the electoral commission.

In Sidi Bouzid, soldiers fired warning shots after hundreds of alleged supporters of Areedhya Chaabiya flooded the streets and burned tires, according to a witness reached by telephone, Attia Athmouni.

The official TAP news agency said people were angry over the invalidation of the six lists of Areedha Chaabiya.

However, earlier in the day, some residents had already expressed displeasure with reported remarks from an Ennahda official scolding the population for letting money sway their votes.

Areedha Chaabiya's leader, Hachemi Hamdi, a native son of Sidi Bouzid and owner of the Mustaqila satellite television channel based in London, had broadcast promises to give Tunisians free health care, new factories and thousands of jobs.

Electoral officials ultimately invalidated five lists tarnished by financing violations and one led by a former member of the ruling RCD party ? now banned.

Protests spread to nearby Menzel Bouzayane where more than 1,000 people demonstrated, union official Mohamed Fadhel said by telephone.In Meknassy, 50 kilometers from Sidi Bouzid, demonstrators set fire to Ennahda's party office, Fadhel said.

Ennahda's leading role in fashioning a new Tunisia was evident shortly after the vote. However, electoral authorities had said they were slow in announcing full results because they were taking care with counting and verifying.

Officials of the party have said they are seeking a broad-based coalition government to replace the interim team in charge of this small North African nation since protests forced President Zine El Abidine Ben Ali to flee in January. He took refuge in Saudi Arabia.

Ennahda has also vowed to wary Tunisians that democratic liberties such as gender equality will be respected in line with Muslim Tunisia's strong secular tradition.

International observers praised Tunisia for an exemplary election.

Tunisia's path forward is under scrutiny after it led the way for Arab neighbors in casting off dictators, in Egypt and later in Libya ? proclaimed liberated last Sunday as Tunisians went in droves to the polls.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2011-10-27-ML-Tunisia-Elections/id-7cfaf220feec41f5bd65a9a76820efcc

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How do you bounce back from this?

Exhausting. Thrilling. Harrowing. Spectacular. One of the reasons I?m having such a hard time writing about Game 6 today is because the adjectives we?ve developed over the thousands of years of human speech are rather insufficient. I?m still reeling myself.

But one question some people have asked me today is how on Earth, after coming within one strike of winning the World Series last night, only to fritter it away on multiple occasions, can the Rangers bounce back? ?My response to that is: what, are you crazy?

Nothing in this World Series has gone as expected. Nothing can be predicted based on the previous game?s results. I would just as soon predict that the Rangers will activate Nolan Ryan and the Cardinals will active Bob Gibson and we?d have an exact reenactment of Game 7 from 1991 than I would predict that the Rangers would be unable to muster the emotional energy necessary to win tonight.

Remember 1986? After Buckner? The Red Sox had a 3-0 lead heading into the bottom of the sixth inning in Game 7. ?Yes, they lost, but the ?oh, they?re?devastated? narrative didn?t hold up. ?Tired bullpens, the Mets execution and the Red Sox? lack thereof is what decided that game, not momentum. ?To suggest otherwise is to impose a storyline we want to impose, not to reflect what happened. Or what we can at least accurately ascertain happened.

And so is the case tonight. ?Not having Derek Holland at the ready is going to be a way taller order for the Rangers to overcome than shell shock from Game 6. ?The fact that they?re on the road and that the home team has won the last eight Game sevens will matter more than shell shock too (though that?s not a predictive thing either). ?The Rangers? defense ? if as bad as it was in Game 6 ? will play a huge role too.

But let?s save the drama-spinning for a while, OK?

Source: http://hardballtalk.nbcsports.com/2011/10/28/can-the-rangers-bounce-back-after-last-nights-game/related

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Facebook confirms data center near Arctic Circle (AP)

STOCKHOLM ? Facebook says its new server farm on the edge of the Arctic Circle ? its first outside the U.S. ? will improve performance for European users of the social networking site.

After reviewing potential sites across Europe, Facebook confirmed Thursday it had picked the northern Swedish city of Lulea for the data center partly because of the cold climate ? crucial for keeping the servers cool ? and access to renewable energy from nearby hydropower facilities.

The move reflects the growing international presence of the California-based site, which counts 800 million users worldwide.

"Facebook has more users outside the U.S. than inside," Facebook director of site operations Tom Furlong told The Associated Press. "It was time for us to expand in Europe."

He said European users would get better performance from having a node for data traffic closer to them. Facebook currently stores data at sites in California, Virginia and Oregon and is building another facility in North Carolina.

The Lulea data center, which will consist of three 300,000-square foot (28,000-square meter) server buildings, is scheduled for completion by 2014. The site will need 120 MW of energy, fully derived from hydropower.

Located 60 miles (100 kilometers), south of the Arctic Cicle, Lulea lies near hydropower stations on a river that generates twice as much electricity as the Hoover Dam on the border of Nevada and Arizona, Facebook said.

In case of a blackout, construction designs call for each building to have 14 backup diesel generators with a total output of 40 MW.

Facebook didn't give the price of its investment, but Lulea officials have previously projected construction costs of up to 5 billion kronor ($760 million).

"We knocked on doors at Facebook's head office (in Palo Alto, California) and today they're moving in to Lulea ? this is huge, really huge," said Matz Engman, who heads the Lulea Business Agency, a public-private partnership working to attract businesses to the region.

With winter temperatures well below freezing and summertime highs that rarely climb above 80F (25 degrees Celcius), Lulea has used its frigid climate as a selling point in its efforts to establish itself as a hub for server farms. Other Nordic cities have adopted similar strategies.

In 2009 Google purchased a paper mill in Hamina, southern Finland, and turned it into a data center, using seawater from the Baltic Sea for its cooling system.

Servers inside data centers are the backbone of Internet services such as Facebook. The servers store and transmit billions of status updates, links, photos and all the outside apps used by Facebook's members.

___

Associated Press writer Malin Rising contributed to this report.

Source: http://us.rd.yahoo.com/dailynews/rss/europe/*http%3A//news.yahoo.com/s/ap/20111027/ap_on_hi_te/eu_sweden_facebook_server_farm

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Michael Lohan Arrested ? for the Second Time This Week!

A few words of advice for Michael Lohan: When you've just been released from jail after your ex had you arrested for alleged domestic abuse, it's probably best not to harrass her with threatening phone calls.

Source: http://www.ivillage.com/michael-lohan-arrested-second-time-week/1-a-396676?dst=iv%3AiVillage%3Amichael-lohan-arrested-second-time-week-396676

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Officer: He believed woman's home invasion story (AP)

FORT DODGE, Iowa ? A local detective who interviewed an Iowa woman the night she killed her 20-year-old neighbor believed she was telling the truth about defending herself during a home invasion and assault, but a high-level state investigator was immediately skeptical, according to testimony Thursday in her murder trial.

Former Sac County sheriff's Lt. Dennis Cessford testified that he believed Tracey Richter's demeanor in the hospital and bruises on her neck, hands and legs were consistent with her claims of self-defense. Cessford said Richter appeared concerned and perhaps scared when he interviewed her at a local hospital.

"We took Tracey's information at face value," he said.

But retired Division of Criminal Investigation crime scene team supervisor Robert Harvey said he saw no signs of a forced entry or a struggle when he arrived at the home hours after the slaying.

Richter, 45, of Omaha, Neb., is charged with first-degree murder in the Dec. 13, 2001, death of Dustin Wehde at her former home in Early, a town in northwest Iowa. Prosecutors say she shot Wehde, planted a notebook in his car that implicated her ex-husband in a murder-for-hire scheme and then falsely claimed she was a victim of a home invasion.

Richter has claimed all along that she shot Wehde to protect herself and her three children after Wehde and another man broke into her home and strangled her with pantyhose. She claims that she was able to break free, unlock her gun safe, grab a gun and shoot Wehde over her shoulder. She says she then shot him again with a second gun after he was trying to get up.

Cessford said that one thing that "bothered me" about her story was the way she used two guns, ending up with one in each hand. He said that was something he had not seen in his experience or would have thought to do himself.

Prosecutors had Harvey walk jurors through gruesome photographs he took of Wehde, slumped over on the bedroom's hardwood floor with a pool of blood around his head. Richter covered her eyes for the most graphic shot and but occasionally looked at the television screen as other photos showing blood running across the floor, the gun safe and bullet fragments were broadcast.

Harvey, who retired in 2006 after three decades with DCI, testified he arrived at the home hours after the shooting and was immediately skeptical that a break-in and assault had occurred.

He said investigators examined all the doors and saw no signs of a forced entry. He said there also were no items in the house that were knocked over or out of place that would have suggested a struggle. He said he did find a pair of pantyhose on the kitchen floor, a baseball bat and a revolver on the kitchen counter.

"In a struggle you would have a tendency to run into things and knock things over ... none of that was there," said Harvey, who retired in 2006.

Cessford said law enforcement officials found a pink spiral notebook in the front of Wehde's car the day after the shooting in which he had written that Richter's ex-husband had hired him to kill her and her 11-year-old son and make it look like a murder-suicide. He said police decided immediately to keep the notebook a secret because "that would be a key piece of evidence that only the person responsible for that evidence would know about it and talk about it."

Cessford said investigators looked at whether Richter's husband at the time, Michael Roberts, was involved in the events leading up to the shooting but ruled him out after determining he had been out of state on business. But under cross-examination from Richter's defense lawyer Scott Bandstra, the officer acknowledged that prosecutors no longer have the cell phone records he reviewed that helped him reach that conclusion.

Bandstra has suggested that another man was the alleged second intruder, but part of the defense strategy also appears to be raising doubts about Roberts' potential involvement. The defense noted Wednesday that Roberts had planned a business trip during the shooting and gave an employee who went with him a $5,000 bonus and a $20,000 raise shortly afterward. The employee testified the pay increase was for his performance and had nothing to do with the shooting.

Source: http://us.rd.yahoo.com/dailynews/rss/crime/*http%3A//news.yahoo.com/s/ap/20111027/ap_on_re_us/us_hero_mom_or_killer

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Daily App Deals: Inspire Pro for iPad on Sale in Today's App Deals [Deals]

Daily App Deals: Inspire Pro for iPad on Sale in Today's App DealsThe Daily App Deals post is a round-up of the best app discounts of the day, as well as some notable mentions for ones that are on sale.

The Best

Daily App Deals: Inspire Pro for iPad on Sale in Today's App DealsInspire Pro - Paint, Draw & Sketch (iTunes) Previously $7.99, now $0.99 (Limited Time) . Inspire Pro for the iPad is a paint app that simulates wet oil paint on canvas with a realistic look and feel. Get it for $0.99. (via LogicBuy)

Free

iOS

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/SXs2J8NDY_0/daily-app-deals-inspire-pro-for-ipad-on-sale-in-todays-app-deals

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Climate unknown: How serious the threat to life is

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Pressed by EU, Berlusconi reaches pension deal

Northern League's leader Umberto Bossi lights a cigar as he sits in a bar next to the Chamber of Deputies building in Rome Tuesday, Oct. 25, 2011. Ministers and lawmakers on Monday were debating measures aimed at raising the retirement age to match that of Germany, which is raising its retirement age to 67 for anyone born after 1964. However, any change in Italy's retirement age will face fierce resistance from Berlusconi's main political ally, the Northern League, whose constituency includes workers in Italy's productive north. Unions also oppose raising the pension age, as the European Union demanded Italy introduce tough new measures to spur economic growth. (AP Photo/Lapresse, Mauro Scrobogna)

Northern League's leader Umberto Bossi lights a cigar as he sits in a bar next to the Chamber of Deputies building in Rome Tuesday, Oct. 25, 2011. Ministers and lawmakers on Monday were debating measures aimed at raising the retirement age to match that of Germany, which is raising its retirement age to 67 for anyone born after 1964. However, any change in Italy's retirement age will face fierce resistance from Berlusconi's main political ally, the Northern League, whose constituency includes workers in Italy's productive north. Unions also oppose raising the pension age, as the European Union demanded Italy introduce tough new measures to spur economic growth. (AP Photo/Lapresse, Mauro Scrobogna)

MILAN (AP) ? Italian Premier Silvio Berlusconi averted a government collapse and reached a deal with allies on emergency growth measures in time for an EU summit on saving the euro before political tensions erupted in a fist fight in parliament.

Berlusconi and Northern League leader Umberto Bossi reached a compromise on raising Italy's retirement age in late-night parliament talks Tuesday ? a point of disagreement that had threatened Berlusconi's leadership. His majority in parliament needs the support of the Northern League.

A fist fight in the Chamber of Deputies on Wednesday when League lawmakers briefly came to blows with colleagues loyal to a former Berlusconi ally Gianfranco Fini, the Chamber president who broke with the governing coalition early in its term. Scuffles are not rare in Italy's parliament.

League deputies were incensed when Fini, on a TV talk show, mentioned that Bossi's wife, took early retirement from a teaching job when she was 39.

Berlusconi will deliver a letter detailing the emergency measures to an EU summit. A spokesman said the contents are reserved for summit leaders, but Italian media reported the measures include new infrastructure spending, with a push for more private investment for strategic projects, the privatization of public entities and property and simplifying rules for companies.

Changes to Italy's pension scheme had become a major sticking point, with Bossi's party refusing to risk alienating its constituency of workers from the productive north.

Under the overnight deal, Italy will gradually raise the pension age for all workers to 67 by 2025, bringing it in line with European trends. Currently, Italian men retire at 65 along with women in the public sector but some women in the private sector retire earlier.

The 15-page letter also reportedly contains details of the euro54 billion ($75 billion) in austerity measures passed by lawmakers last month to balance Italy's budget by 2013.

The European Union had asked for measures, with a clear calendar for implementation, to promote growth, raise the pension age and simplify civil legal proceedings to encourage foreign investment

Outgoing Bank of Italy governor Mario Draghi called the letter of intent "an important step ... but now it's time to implement the measures swiftly and concretely." Draghi, who takes over helm of the European Central Bank on Nov. 1, also urged Berlusconi's government to quickly activate the spending cuts and new taxes approved last month.

In Brussels, a spokesman for the European commission, Olivier Bailly, said the EU was "confident" it would have the letter by the end of the day.

Italy is seen as the next country at risk in the widening sovereign debt crisis, but with euro1.9 trillion ($2.6 trillion) in public debt, an Italian default would be disastrous for the global economy. The European Central Bank for months has been buying billions in Italian bonds to help keep borrowing costs down.

Nonetheless, Italy saw borrowing costs on short-term bonds spike Wednesday. The Italian Treasury sold euro8.5 billion ($11.83 billion) in six-month bonds at 3.53 percent, up sharply from last month's 3.071 percent, its highest level in three years. Yields on two-year bonds rose to 4.628 percent from 4.511.

A Berlusconi spokesman, meanwhile, brushed off reports that Berlusconi was preparing to resign. The left-leaning La Repubblica newspaper, one of Berlusconi's staunchest critics, reported that he had threatened to resign if no deal could be reached with the Northern League, which was persisting in its resistance to raising the retirement age.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2011-10-26-EU-Italy-Financial-Crisis/id-79d78c51e04940489dcc0bc06f02af18

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Blood vessel mapping reveals four new 'ZIP codes'; Targeting specific addresses could help fight cancer, obesity and other diseases

ScienceDaily (Oct. 24, 2011) ? A research team led by scientists from The University of Texas MD Anderson Cancer Center has discovered four new "ZIP codes" in their quest to map the vast blood vessel network of the human body.

The study, published online the week of Oct. 24 in the Proceedings of the National Academy of Sciences, brings science one step closer to the goal of using the vascular system to personalize cancer therapy, as well as fight obesity, heart disease and other disorders. Researchers also found that some addresses are shared in vasculature across the board instead of always being organ-specific.

The study is part of ongoing research to identify specific and unique addresses, or ZIP codes, within the body's vascular system and use them to develop diagnostic, imaging and therapeutic strategies. Husband-and-wife research team Wadih Arap, M.D., Ph.D., and Renata Pasqualini, Ph.D., professors at the David H. Koch Center for Applied Research of Genitourinary Cancers at MD Anderson, pioneered the concept and were senior authors of the paper.

"By identifying vascular ZIP codes, we bring medicine closer to the ultimate goal of targeted therapies," Pasqualini said.

Innovative methods help investigation

This study supports the Arap-Pasqualini lab's ongoing research to show blood vessels are more than a uniform and ubiquitous "pipeline" that serves the circulatory system.

More than a decade ago, the group pioneered a screening technique that employs billions of viral particles, called phage, to discover, validate and use blood vessel diversity. The particles are packaged with small fragments of proteins called peptides that act as ligands. When injected into the body, they bind to specific receptors in the blood vessels and organs.

"This process is like a 'molecular mass mailing' to all addresses in the body," Arap said. "The peptides travel until they find a target and bind to it, then with our novel technology we recover and identify them. Knowing the characteristics of the peptides and where they attach can help us understand the vascular system's molecular makeup and develop therapies focusing on disease sites."

This new study was the first in which researchers evaluated the molecular repertoire of protein diversity in several patients, targeting multiple organs at once.

In three cancer patients, serial rounds of peptide collection were followed by biopsies from various tissues to determine where and how the peptides homed, which enabled the enrichment of targeting peptides for identifying ligand-receptors. After systemic delivery of a peptide library to the first patient, phage were recovered from organs, pooled and serially screened in two subsequent patients. Large-scale sequencing was then performed.

"This uncovered a new twist for the vascular map," Pasqualini said. "To this point, we had seen mainly addresses that were organ and tissue specific. Because of this synchronized method, we discovered some markers are vascular-associated at multiple sites."

Shared addresses surprise researchers

Analysis revealed four native ligand-receptors, three of which were previously unrecognized.

Two are shared among multiple tissues (integrin a4/annexin A4 and cathepsin B/apolipoprotein E3) and the other two have a restricted and specific distribution in normal tissue (prohibitin/ annexin A2 in white fat tissue) or cancer (RAGE/leukocyte proteinase-3 in bone metastases).

The discovery of shared addresses especially intrigued researchers.

"No one knew about the novel aspect surrounding these particular proteins, and the fact that they can interact and come together to serve a common purpose," Pasqualini said. "There are likely to be many more."

A tissue-specific vascular-targeting system, comprising ANXA2 and prohibitin, was found as a ligand-receptor in human white adipose (fat) tissue vasculature. In earlier research, targeting of prohibitin with an apoptotic agent caused dramatic weight loss in obese rodents. The lab is applying to the Food and Drug Administration (FDA) to conduct a clinical trial for a new drug that will test this principle for weight loss in humans. Moving the impact forward This project establishes that large-scale study of the human vasculature can uncover many unidentified or unique molecular networks that can contribute to the treatment of many diseases.

"This endeavor and the applications of our findings are exciting," Arap said. "There are going to be many more receptors and many levels of diversity. We've just scratched the surface."

Translational applications, such as first-in-man clinical trials, have started within MD Anderson. The FDA has granted a safe-to-proceed status for the first vascular-targeted Investigational New Drug (IND). Three other drugs are in pre-IND stage, and several others are in pre-clinical laboratory phase.

"I believe these strategies to identify therapeutic targets on the vasculature are truly innovative both from a scientific and clinical perspective," said David Cheresh, Ph.D., associate director for Translational Research at the University of California, San Diego Cancer Center and noted authority on angiogenesis and cancer metastasis. "Identifying such targets will ultimately pave the way for the next generation of smart/targeted cancer therapies."

MD Anderson and some of its researchers, including Arap and Pasqualini, have equity positions in drug-development companies Alvos Therapeutics and Ablaris Therapeutics, which are subjected to certain restrictions under institutional policy. MD Anderson manages and monitors the terms of these arrangements in accordance with its conflict-of-interest policy.

Co-authors from MD Anderson's David H. Koch Center are first authors Fernanda Staquicini, Ph.D., Marina Card?-Vila, Ph.D., and Mikhail Kolonin, Ph.D. Additional authors include Julianna Edwards; Diana Nunes, Ph.D., and Emmanuel Dias-Neto, Ph.D., Eleni Efstathiou, M.D., Ph.D.; Jessica Sun, and Christopher Logothetis, M.D.

Other MD Anderson contributors include Anna Sergeeva, Ph.D., Department of Stem Cell Transplantation; Shi-Ming Tu, M.D., Department of Genitourinary Medical Oncology; Jeffrey Gershenwald, M.D., Department of Surgical Oncology; Jeffrey Molldrem, M.D., Department of Stem Cell Transplantation; Anne Flamm, J.D., Department of Clinical Ethics ; Erkki Koivunen, Ph.D., Department of Leukemia; Rebecca Pentz, Ph.D., Department of Clinical Ethics; Patricia Troncoso, M.D., Department of Pathology; Kim-Ahn Do, Ph.D., Department of Biostatistics; Gregory Botz, M.D., Department of Critical Care; and Michael Wallace, M.D., Department of Diagnostic Radiology.

Additional contributors included Martin Trepel, M.D., University Medical Center of Hamburg; Nalvo Almeida, Ph.D., and Jo?o Setubal, Ph.D., Virginia Bioinformatics Institute and Department of Computer Science, Virginia Polytechnic University; Stan Krajewski, M.D., Ph.D., at The Sanford-Burnham Medical Research Institute; Richard Sidman, M.D., (corresponding author), Beth Israel Deaconess Medical Center and Harvard Medical School; Dolores Cahill, Ph.D., and David O'Connell, Ph.D., Conway Institute of Biomedical and Biomolecular Science, University College Dublin.

This work was funded by grants from the National Institutes of Health, National Cancer Institute, the U.S. Department of Defense, AngelWorks, the Gillson-Longenbaugh Foundation and the Marcus Foundation.

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Source: http://www.sciencedaily.com/releases/2011/10/111024172740.htm

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Caterpillar quarterly earnings jump 44 percent (Reuters)

(Reuters) ? Caterpillar Inc far exceeded analyst expectations on Monday, reporting a 44 percent quarterly earnings increase due to record revenue, and the company signaled optimism in its 2012 outlook.

The Peoria, Illinois, company said it expects full-year 2011 profit and revenue to be at the top end of its previous outlook range due to strong demand. In 2012, the company sees revenue increasing 10 percent to 20 percent above the $58 billion in sales it expects this year, although it continues to make contingency plans for a potential downturn.

Caterpillar said it ended the third quarter in one of the healthiest positions in its recent history. Backlog orders standing at record levels and higher commodity prices leading to a favorable environment for its growing mining business. The company expects to post record results in 2011 and improve on those results next year.

Construction activity is increasing in developing markets, while buyers in more mature markets -- such as the United States -- are buying new machinery in order to replace aging fleets rather than investing for growth. Equipment-rental operators are also purchasing new equipment in order to freshen their fleets, the company said.

Caterpillar's shares traded significantly higher in Monday's session, leading an overall rally in the market. The stock gained about 6.3 percent, or $5.45, to $92.84 on the New York Stock Exchange.

SLOW-GROWTH ECONOMY SEEN

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Caterpillar reported third-quarter earnings that far exceeded expectations http://link.reuters.com/byj64s

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The world's largest heavy machinery manufacturer is one of a slate of industrial companies outpacing analyst expectations during the current earnings reporting season. Like some of its peers, the company is encouraged by the strong results even as it remains cautious about the wider economy due to mixed economic data and tightening in key growth markets, such as China.

"Although there is a good deal of economic and political uncertainty in the world, we are not seeing it much in our business at this point," Caterpillar Chief Executive Doug Oberhelman said in a press release. "We believe continued economic recovery, albeit a slow recovery, is the most likely scenario as we move forward."

Caterpillar's outlook indicates the company is successfully "coming to grips with a slower global economy," Longbow Research equity analyst Eli Lustgarten said. Caterpillar is able to succeed in the cloudy environment due to "very big growth outside of the United States and what's been a very strong (machinery) replenishment rate in the U.S.," he said.

The company was able to outpace analyst expectations during the third quarter due to considerably higher revenue, much of which came from the rebuilding of inventory as dealers looked to build stock. Analysts continue to express concern over the health of the so-called end users of Caterpillar products.

Caterpillar said heavy machinery supplies would likely remain "tight" in 2012, and the company plans to continue increasing production levels for many of its products. "We are making strategic investments in our business to position Caterpillar for continued success well beyond 2012," Oberhelman said.

In 2012, Caterpillar expects to achieve sales increases in mature markets, up from what it currently views as "low levels" of sales activity. Growth in emerging markets next year is expected to keep pace with the rate seen in 2011.

The company did caution that it is seeing a bit of a slowdown in China's demand levels due to measures the government is taking to tighten the economy. Caterpillar executives, speaking on a conference call, said the slowdown is needed and indicated the company continues to build market share in that market.

Caterpillar reported third-quarter net income attributable to common shareholders of $1.14 billion, or $1.71 per share, compared with $792 million, or $1.22 per share, a year ago.

Analysts on average had expected Caterpillar to earn $1.54 per share in the third quarter.

Sales rose 41 percent to $15.7 billion, which is a record, according to the company.

The company noted that operating cash flow in its Machinery and Power Systems business nearly doubled over the first three quarters compared with the same period in 2010.

Caterpillar said full-year 2011 results would come in at the highest end of its previous outlook. It now expects annual revenue of $58 billion, including its acquisition of the Bucyrus mining business this year. Its previous forecast had been a range of $56 billion to $58 billion.

Profit is now expected to be $6.75 per share for the year, compared with a prior forecast of $6.25 to $6.75. Including the impact of Bucyrus, Caterpillar expects 2011 profit to reach $7.25 per share.

The company said 2011 will be a record year if it hits its earnings and revenue expectations.

Caterpillar said it added 4,800 jobs during the quarter, including 2,000 in the United States.

(Reporting by John D. Stoll in Detroit; Editing by Lisa Von Ahn, Maureen Bavdek and Gunna Dickson)

Source: http://us.rd.yahoo.com/dailynews/rss/economy/*http%3A//news.yahoo.com/s/nm/20111024/bs_nm/us_caterpillar

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